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"The dose makes the poison" ((ラテン語:''sola dosis facit venenum'')) is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim "All things are poison and nothing is without poison; only the dose makes a thing not a poison." This is often condensed to: "The dose makes the poison" or in Latin "Sola dosis facit venenum". It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration (i.e., dose).〔(The Dose Makes the Poison on Chemsafe at Yale )〕 The principle relies on the finding that all chemicals—even water and oxygen—can be toxic if too much is eaten, drunk, or absorbed. "The toxicity of any particular chemical depends on many factors, including the extent to which it enters an individual’s body."〔(Nancy Trautmann: The Dose Makes the Poison--Or Does It? ), Bioscience 2005, American Institute of Biological Sciences〕 This finding provides also the basis for public health standards, which specify maximum acceptable concentrations of various contaminants in food, public drinking water, and the environment.〔 However, there is no linear relationship and also more to chemical toxicity than the acute effects caused by short-term exposure. Relatively low doses of contaminants in water, food, and environment can already have significant chronic effects if there is a long-term exposure.〔 Many pollutants, drugs and natural substances adhere to this principle by causing different effects at different levels, which can as a result lead to health standards that are either too strong or too weak.〔(Pete Myers, Ph.D. and Wendy Hessler: Does 'the dose make the poison?' (englisch) )〕 Generally the effects of different doses can be very different at different levels (not only bigger and smaller impacts depending on dose). Very low doses of some compounds can even induce stronger toxic responses than much higher doses as well as just different impacts.〔 ==Toxic substances and the law== "Regulators must extrapolate results not only from animal toxicity studies, typically from mice and/or rats to humans, but also from the very high doses usually used in animal experiments to the very low doses that are characteristic of human exposure. These two types of extrapolation are steeped in uncertainty," wrote Edward J. Calabrese, Professor of Toxicology at the University of Massachusetts Amherst' School of Public Health in Amherst, MA, USA.〔(Hormesis: a revolution in toxicology, risk assessment and medicine ) EMBO Rep. 2004 October; 5(Suppl 1): pp. 37–40. .〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「The dose makes the poison」の詳細全文を読む スポンサード リンク
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